PMI VectorLink Ghana works to bring indoor residual spraying (IRS) to hard-to-reach communities by working with the government of Ghana to implement IRS in nine districts. They reach nearly 1,500 communities, close to 18 percent of which are in hard-to-reach areas. Some of these areas are only accessible through roads that can become impassible during heavy rains; others are nestled between mountains and can only be reached on foot. Successful implementation of IRS in hard-to-reach communities is thanks to dedicated communities and their leadership, supportive stakeholders, and committed governments in Ghana and the United States.